A group of researchers from Artavanis-Tsakonas Laboratory at Harvard Medical School published their research on genetic circuitry that conditions the clinical severity of spinal muscular atrophy (SMA). Back in 2011 researchers from Artavanis-Tsakonas Laboratory also published a protein interaction map in common fruit fly (Drosophilia melanogaster).
The clinical severity of SMA is dependent on the levels of functional Survival Motor Neuron (SMN) protein. Consequently, current strategies for developing treatments for SMA generally focus on augmenting SMN levels.
To identify additional potential therapeutic avenues and achieve a greater understanding of SMN, they applied different approaches to identify genetic and biochemical interactors of the Drosophila SMN equivalent. More than 300 candidate genes that alter an Smn-dependent phenotype were identified. Integrating the results from the genetic screens, large-scale protein interaction studies, and bioinformatic analysis, they defined a unique interactome for SMN that provides a knowledge base for a better understanding of SMA.
Read the whole article here.
The clinical severity of SMA is dependent on the levels of functional Survival Motor Neuron (SMN) protein. Consequently, current strategies for developing treatments for SMA generally focus on augmenting SMN levels.
To identify additional potential therapeutic avenues and achieve a greater understanding of SMN, they applied different approaches to identify genetic and biochemical interactors of the Drosophila SMN equivalent. More than 300 candidate genes that alter an Smn-dependent phenotype were identified. Integrating the results from the genetic screens, large-scale protein interaction studies, and bioinformatic analysis, they defined a unique interactome for SMN that provides a knowledge base for a better understanding of SMA.
Read the whole article here.
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